BCHE-BIOCHEMISTRY (BCHE)

BCHE 140. Introduction to Biochemistry

1 Credit

A description of the nature of inquiry in biochemistry, especially with respect to the interaction of chemistry and biology. Both historical development and topics of current interest will be discussed. Graded S/U.

BCHE 241. Introduction to Research in Biochemistry

1-3 Credits

Techniques and procedures of biochemical research. May be repeated for a maximum of 3 credits.

Prerequisites: 8 credits of chemistry and 3.0 GPA in chemistry.

BCHE 341. Survey of Biochemistry

4 Credits (3+3P)

Basic principles of biochemical processes and the structure/function of the major classes of biomolecules, with introductions to metabolism and the central dogma of biochemistry. The chemical and biological properties of major biomolecules (DNA, proteins,

Prerequisite(s): C or better in CHEM 211 or CHEM 313.

BCHE 395. Biochemistry I

3 Credits

Principles governing chemistry and physics of life processes with emphasis on the relationships between molecular structure and cell function. Basic principles of biochemical processes, enzymology, and the structure/function of the major classes of biomolecules with introductions to metabolism. Introduction to catabolic metabolism.

Prerequisite(s): C or better in CHEM 314.

BCHE 396. Biochemistry II

3 Credits

Introduction to anabolic metabolism and hormonal regulation. Biochemical principles of the mechanism and regulation of replication, transcription, recombination and translation in prokaryotes and eukaryotes. Introduction to DNA-based information technology. Taught with BCHE 396 H.

Prerequisite(s): C or better in BCHE 395.

BCHE 396 H. Biochemistry II Honors

3 Credits

Taught with BCHE 396 with additional work required.

BCHE 397. Experimental Biochemistry Laboratory

3 Credits

Introduction to fundamental techniques used to explore structure and function of biological macromolecules such as proteins, carbohydrates, lipids, and nucleic acid. Course covers analyzing and reporting experimental data; enzymology; quantitative methods to determine biological molecules; basic principles of electrophoresis, chromatography, and spectroscopic immunochemistry.

Prerequisite: C or better in BCHE 395.

Corequisite: BCHE 396.

BCHE 432. Physical Biochemistry

3 Credits

This course focuses on modern Biophysical techniques used in protein and nucleic acid research. Topics are covered in some detail at the theoretical level. The course content is delivered entirely by podcast. Podcast contributions are from several different faculty from within their particular area(s) of expertise. Topics covered include (but are not limited to): biomolecular NMR, atomic force microscopy, light scattering, circular dichroism, ultracentrifugation, isothermal titration calorimetry, positron emission tomography, computerized tomography, ultrasound, functional MRI, protein fluorescence, mass spec/ proteomics, protein molecular dynamics simulations, and X-ray diffraction. Course credit qualifies for minor degree in chemistry as a physical-analytical chemistry emphasis. CHEM 431, or CHEM 433.

Prerequisite: One semester of undergraduate physical chemistry, e.g.

BCHE 440. Biochemistry Seminar

1 Credit

Introduction to current literature in biochemistry and molecular biology. Selected topics in the field will be presented by the faculty. Students will present written and oral reports from literature searches. Restricted to: BCHE majors.

Prerequisite(s): BCHE 395.

BCHE 441. Advanced Research in Biochemistry

1-3 Credits

Investigation of biochemical problems and the development of special techniques. May be repeated for a maximum of 3 credits.

Prerequisites: consent of instructor, 16 credits of chemistry and 3.0 GPA in chemistry for nonmajors.

BCHE 446. Biochemistry III

3 Credits

Intermediary metabolism of carbohydrates, lipids, amino acids, and nucleic acids. Metabolic pathways discussed with emphasis on biochemical regulation and mechanistic, structural, functional, and evolutionary basis for existence.

Prerequisite(s): BCHE 395 and either BCHE 396 or consent of instructor.

BCHE 451. Special Topics

1-3 Credits

Same as CHEM 451. May be repeated for a maximum of 12 credits.

Prerequisite: consent of instructor.

BCHE 455. Independent Studies

1-3 Credits

Independent studies directed by consulting faculty.

Prerequisite: consent of instructor.

BCHE 494. Biochemical Genetics Laboratory

3 Credits (1.25+6P)

Laboratory techniques required for experimentation with recombinant DNA such as nucleic acid isolation and purification, polymerase chain reaction (PCR), sequence analysis, and directed mutagenesis using genetic material from both prokaryotic and eukaryotic organisms. Consent of Instructor required.

Prerequisite(s): C or better in BCHE 395 and BCHE 396 or GENE 315, and consent of instructor.

BCHE 540. Seminar in Biochemistry

1 Credit

Formal seminar presentation in current topics in biochemical research. May be repeated for a maximum of 3 credits.

BCHE 542. Biochemistry I

3 Credits

Relationship between macromolecular structure and function. Basic enzymology. Energy metabolism.

Prerequisite(s): CHEM 314 and CHEM 431 or CHEM 433; or BCHE 395 or equivalent.

BCHE 545. Molecular and Biochemical Genetics

3 Credits

An accelerated treatment of the molecular basis of gene expression. Discussion of chemical, enzymological, and genetic techniques of molecular biology. Same as BIOL 545.

Prerequisite: BCHE 542 or equivalent.

BCHE 546. Biochemistry II

3 Credits

Intermediary metabolism: catabolic and anabolic pathways of carbohydrates, lipids, amino acids, and nucleic acids, including their regulation.

Prerequisite: BCHE 542 or BCHE 395 with consent of instructor.

BCHE 590. Discussions in Biochemistry

1 Credit

Current research problems in biochemistry. May be repeated for a maximum of 6 credits. S/U Grading (S/U, Audit).

BCHE 598. Special Research Programs

1-3 Credits

May be repeated for a maximum of 6 credits. Same as CHEM 598. Graded S/U.

BCHE 599. Master's Thesis

15 Credits

May be repeated for a maximum of 6 credits. Same as CHEM 599.

BCHE 600. Research

1-15 Credits

May be repeated for a maximum of 20 credits. PR/U grading. Same as CHEM 600.

BCHE 645. Nucleic Acid Metabolism

3 Credits

Study of the enzymology of proteins that act on nucleic acids as well as the effect of DNA and RNA structure on metabolic processes. Taught with BCHE 451.

Prerequisite(s): 'C' or better in BCHE 395 or BCHE 542.

BCHE 647. Physical Biochemistry

3 Credits

Fundamental applications of physical chemistry to the investigation of biological metabolites and biological macromolecules, including proteins, oligo-nucleotides, and molecular arrays with an emphasis on understanding biological functions based on chemical structures. Taught with BCHE 451.

Prerequisite(s): 'C' or better in CHEM 431 or CHEM 433 or BCHE 542.

BCHE 649. Topics in Biochemistry

1-3 Credits

Selected topics of current interest designated by title and credit. May be repeated for a maximum of 3 credits.

BCHE 650. Advanced Seminar

1 Credit

Discussion of biochemical research in progress that relates to a doctoral candidate's thesis research. Intended for students who have earned a master's degree or the equivalent and has made significant research progress for preparation of the doctoral dissertation. May be repeated for a maximum of 3 credits.

BCHE 700. Doctoral Dissertation

20 Credits

May be repeated for a maximum of 20 credits. Graded PR/U. Same as CHEM 700.